Endocrine Abstracts

This topic will be discussed taking into consideration the need to incorporate the continuously increasing molecular data in the old frame (imagiology, cyto and histopathology and biochemistry). Using this strategy three practical issues may be addressed: diagnosis, prognosis/therapy selection and surveillance.Out of the above mentioned issues we will focus the discussion of the usefulness of molecular markers in two steps of the management of patients w...

Introduction: The management of small size (≤ 1 cm) papillary thyroid carcinoma, also known as papillary thyroid microcarcinoma (PTMC) is a debated topic as it includes tumors with a wide range of biological characteristics and behavior.Objectives: To describe prevalence, clinical and histological characteristics of PTMC with excellent response to treatment after a median follow up of 9.85±6.21 years.Methods: We did a re...

Osteopontin (OPN) is a matricellular protein highly expressed in cancer cells, which is able to modulate tumorigenesis and metastasis in several malignancies, including follicular cell-derived thyroid cancers (TC). OPN is one of the gene products aberrantly expressed in TC, but the contribution of each OPN isoform (OPNi), named as OPNa, OPNb and OPNc, is currently unknown. This study aims to analyze the expression profile of OPNi in TC tissue samples, correlate its expression ...

The role of hormones and reproductive factors in thyroid carcinoma is suggested by its higher incidence in women. The association with estrogens or other specific hormonal factors remains unclear. We assessed the estrogen receptor alpha (ESRa), estrogen receptor beta (ESRb) and progesterone receptor (PRR) expression in follicular cell-derived tumours (FDT).Cross-sectional study of 50 (25%) males, median age 50.5 (interquartile range, IR, 34), and 149 (75...

Objectives: At present no European recommendations for the management of pediatric thyroid nodules and differentiated thyroid carcinoma (DTC) exist. Differences in clinical, molecular, and pathological characteristics between pediatric and adult DTC emphasize the need for specific recommendations for the pediatric population.Methods and results: An expert panel was instituted by the executive committee of the European Thyroid Association (ETA) including ...

Context: Little is known about the frequency of key mutations in thyroid cancer metastases and its relationship with the primary tumor genotype.Objectives: To evaluate the frequency of TERT promoter (TERTp), BRAF and NRAS mutations in metastatic thyroid carcinomas, analyzing primary thyroid tumors, lymph node metastases (LNM) and distant metastases.Material and Methods: Mutation analysis was performed in 437 tissue samples from 204...

Objective: One of the hallmarks of cancer is its unlimited replicative potential. Recently, telomerase promoter (TERTp) mutations were presented as novel mechanism for telomerase re-activation/expression. Due to this fact, it was our objective to study pancreatic endocrine tumours (PET) and related cell lines, to determine if TERTp mutations were present.Design: We performed characterization of the TERTp in a series of 55 PETs and three common PET cell l...

Context: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers.Objectives: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognostic significance of such mutations in a large cohort of patients with differentiated thyroid carcinomas (DTC).<p class="abstext"...